According to the most recent guidelines, first-line conventional antiepileptic drugs include fosphenytoin, valproic acid, or levetiracetam (Glauser 2016)
Trial is stopped for any of the following: 1) Persistent resolution of the EEG pattern (and examination repeated)
5 mg/kg)
9 % (601 out of 848 patients; 95 % confidence interval [CI] 67
gov NCT01791868; Status epilepticus (SE) is a neurological emergency with significant morbidity and mortality [1] and requires immediate treatment
Materials and methods: 1
In the Established Status Epilepticus Treatment Trial (ESETT) we compared the efficacy and safety of levetiracetam, fosphenytoin, and valproate Medicine
Phenytoin/fosphenytoin, levetiracetam and valproic acid are evidence choices for second line treatment
Methods: Among 279 adult SE episodes identified prospectively in our tertiary care hospital over 4 years, we retrospectively identified 187 episodes in which PHT, VPA, or LEV were given after benzodiazepines
In this single-center retrospective cohort study we examined if the complications of the intravenous treatment with Status epilepticus is a neurological emergency requiring immediate evaluation and management to prevent significant morbidity or mortality
Although not approved by the US Food and Drug Administration for the treatment of status epilepticus (SE), valproic acid (VPA) is an emerging option for this purpose
Initial seizure management focuses on stabilization of the patient, followed by medication to terminate the seizure
Epilepsy Res
Co-administration of phenytoin and valproic acid is associated with inhibition of the metabolism of Treatment was considered successful when all motor or EEG seizure activity ceased within 20 min after the beginning of the drug infusion and no return of seizure activity during the next 12h
However, based on its potential efficacy and good safety profile, more recent studies indicate that ketamine may be more Treatment with injectable valproic acid resulted in the elimination of all clinical indications of status epilepticus as well as a return to the baseline EEG condition in all four cases
We aimed at analyzing the correlation between VPA loading dose and subsequent plasma levels with clinical response in SE
The SE severity score (STESS), duration of SE and its etiology, and MRI findings were noted
As predicted in previous studies where valproic acid (Depakine®, VPA, sodium valproate) was administered as an oral or rectal loading dose, VPA administered via injection was shown to be effective in the immediate treatment of status epilepticus (SE)
1, 2 Among adults, patients older than 60 had Open Access 01-12-2023 | Status Epilepticus | Research
Moreover, it is a mood stabilizer that has been authorized by the United States Food and Drug Administration for treating several psychiatric disorders, including manic depressive psychosis, major depressive disorder, and posttraumatic stress disorder [1-3]
24 Further treatment of either cortical or subcortical Keywords: carbapenem, valproic acid, drug-drug interaction, critical care outcome, status epilepticus, mortality, healthcare resource
10
Status epilepticus (SE) is a neurologic emergency requiring immediate time-sensitive treatment to minimize neuronal injury and systemic complications
In 2015, the International League Against Epilepsy Task Fo
Methods: Patients who were treated for status epilepticus with intravenous valproic acid between 2008 and 2020 were identified
This is a multicenter, randomized, double-blind, Bayesian adaptive, phase III comparative effectiveness trial
9 % (601 out of 848 patients; 95 % confidence interval
All patients with hyperammonemia were treated at the ICU and all received antibiotics
Although not approved by the US Food and Drug Administration for the treatment of status epilepticus (SE), valproic acid (VPA) is an emerging option for this
Abstract Background Generalised convulsive status epilepticus (GCSE) is a medical emergency
The Valproic Acid as an Adjuvant Treatment for Generalized Convulsive Status Epilepticus (VALSE) trial will evaluate whether the use of VPA as an adjuvant
The efficacy of valproic acid (VPA) in control of generalized convulsive status epilepticus was tested in a rat model
Initial seizure management focuses on stabilization of the patient, followed by medication to terminate the seizure
Valproic acid is a short-chain fatty acid that decreases seizure activity by prolonging the recovery of voltage-gated sodium channels and through effects on GABA metabolism
After more than a century from its discovery, valproic acid (VPA) still represents one of the most efficient antiepi-leptic drugs (AEDs)
Neurocritical Care 2013;18:193–200
The use of valproate and new Objective: To evaluate the efficacy and tolerability of the treatment with valproic acid (VPA) in patients with status epilepticus (SE) or acute repetitive seizures (ARS) comparing it with phenytoin (PHT) treatment
Seizure types included focal, multifocal, and generalized spike and wave forms, suggesting potential benefit from injectable valproic acid treatment in a wide RECOMMENDATIONS
The ongoing Established Status Epilepticus Treatment Trial (ESETT) trial is designed to determine the most effective and/or the least effective urgent treatment of benzodiazepine-refractory status epilepticus in patients older than 2 years
Treatment of convulsive status epilepticus in children and adults: Report of the guideline committee of the In this single-center retrospective cohort study we examined if the complications of the intravenous treatment with valproic acid is different in patients with or without diabetes
Valproic acid had higher efficacy than phenytoin in one study (valproic acid, 66%, vs phenytoin, 42%; The ongoing Established Status Epilepticus Treatment Trial (ESETT) should provide the answer in the next few years
Benzodiazepines are the drugs of choice for SE in pregnancy
9), with a most commonly used dose between 15 and 45 mg/kg in bolus (6 mg/kg/min) followed by 1–3 mg/kg/h infusion
1, 2 Among adults, patients older than 60 had Open Access 01-12-2023 | Status Epilepticus | Research