Stem Cell Reports 17, 307–320 (2022)
Neuropsychiatric manifestations associated with azithromycin in two brothers
The blood–brain barrier, which is one of the tightest barriers in the body, protects the brain from insults, such as infections
When the blood-brain barrier is normal, most beta-lactam agents (eg, penicillin) penetrate poorly
This occurs in two phases of increased permeability of the blood-brain barrier, a physical barrier that under physiologic conditions regulates brain influx and
In short, the sort of damage that we see in the brain with Alzheimer's could be linked to T cells targeting healthy brain cells and the blood-brain barrier being
Optimal antimicrobial treatment of bacterial meningitis requires bactericidal agents able to penetrate the blood-brain barrier (BBB), with efficacy in cerebrospinal fluid (CSF)
METHODS 11 immunocompetent patients with ocular toxoplasmosis were treated with azithromycin (500 mg the first day, followed by 250 mg/day for 5 weeks)
However, some intracellular and extracellular parasites can traverse the BBB during the course of infection and cause
The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood
Anticholinergic agents are the mainstay of pharmacological treatment of OAB; however, many anticholinergics can cross the blood-brain barrier (BBB) and may cause central nervous system (CNS) effects, including cognitive deficits
Some may be quite mild, while others may be very unpleasant
One mechanism by which blood-borne cytokines might affect the function of the central nervous system (CNS) is by crossing the blood-brain barrier (BBB) for direct interaction with CNS tissue
Here, we show a pronounced upregulation of interferon signaling pathways of the neurovascular unit in fatal
Each of the three main CNS interface layers: the BBB, choroid plexus epithelium and the epithelium of the arachnoid mater, functions as a physical, transport, metabolic, and immunologic barrier
PLoS ONE 5 , e13741 (2010)
Cetirizine, a carboxylated metabolite of hydroxyzine, possesses the parent compound's antihistaminic activity but causes
The BBB regulates cellular and molecular exchange between the blood vessels and brain parenchyma