Common side-effects include, colic, gastrointestinal upset and mild diarrhea that may last for days, and sweating over the back and hind legs
Domperidone comes as tablets and a liquid that you swallow
The recommended dosage is 0
One cc will treat 220 lb (100 kg) of body weight
When administering domperidone, make sure the horse's mouth INDICATION For prevention of fescue toxicosis in periparturient mares
5 mg/lb (1
Molecular formula C 22 H 24 CIN 5 O 2
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1 mg/kg) once daily starting 10 to 15 days prior to Expected Foaling Date (EFD)
Drug Acepromazine Use Alpha-1 adrenergic antagonist Sedation Motility stimulant Retention enema for meconium impaction in neonates Complications Vasodilation causing hypotension; avoid in shock or with hemorrhage Dose rate 0
If the endocrine test result on Day 90 was abnormal, the dose increased to 4 mcg/kg given once daily through Day 180
04 mg/kg
8 or 1
Do not use in horses with suspected or confirmed gastrointestinal blockage, as domperidone is a prokinetic drug (it stimulates gut motility)
Nausea and vomiting: Adults—20 milligrams (mg) three to four times daily
Signs of sedation include depression, droopy eyes, and a dropped penis
This should be increased gradually as per the instructions in the individual protocols
Equidone Gel is used for the prevention of fescue toxicosis in periparturient mares
Treatment with Equidone may be continued for up to 5 days after foaling if mares are Medication Brand Name Dosage Altrenogest Regumate 0
5 mg, IM, BID Horses: 1
Twenty-six non-pregnant, non-lactating standardbred anestrous mares were randomly assigned to three groups and treated daily for 25 days (from February 3rd to February 28th) with either sulpiride (1mg/kg of body weight im SID, n=10), or domperidone (1mg/kg po SID, n=10); 6 animals were used as control
Additional safety monitoring was conducted during the field study, as well as a six-month margin of safety study that demonstrated PRASCEND was safe for use in horses at the labeled dosage by performing studies that used 2X the maximum dosage
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At a dose of 0
6 to 10 µg pergolide/kg (0
Horseadvice has nearly 1000 In dogs and cats, the domperidone medical use in secondary agalactia or hypogalactia is recommended at doses of 2
The risk of neurological side effects is higher in young children since metabolic functions and in the blood brain barrier are not fully developed in the first Domperidone D2 dopaminergic antagonist Antiemetic Increases gastroesopha-geal sphincter tone 0
A European review concluded that domperidone is not as effective in this population as Human product; not licensed for use in horses
9 0
May irritate the eyes
The most common endocrine disorders dealt with today by equine practitioners and owners are pituitary pars intermedia dysfunction (PPID, a
5 g/d (the latter being equivalent to the horse dose of 1 mg/kg)
It raises the level of prolactin in the human body and is used to induce and promote breast milk production off label
Adult: As short-term treatment: ≥35 kg: 10 mg up to tid
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Methods: In a 4-period crossover study, domperidone was administered PO at 1
Flunixin meglumine is a non-steroidal, anti-inflammatory drug used as a potent pain reliever, fever reducer, and anti-inflammatory in horses
Domperidone is a medicine that increases the movements or contractions of the stomach and bowel
Diphenhydramine is not FDA approved for use in horses, but it is commonly used and considered acceptable practice
Following the study period the dose was tapered to a twice daily then daily regime before stopping
Sample—18 adult horses and tissue samples from an additional 26 adult horses
The net weight of each syringe is approximately 26 g
It is used for the prevention of fescue toxicosis in periparturient mares
Child 12-17 years (body-weight 35 kg and above) 10 mg up to 3 times a day for a usual maximum of 1 week
There is a chance you may forget to take your Domperidone
Pack size(s): 25ml: Documents:
Fescue toxicosis: 1
DOSAGE AND ADMINISTRATION
DOSE: 20 or 40 mcg/kg = 10 mg or 20 mg/500kg (1100 lb) = 1 or 2 mL/500kg (1100 lb)
10–30 mg (1–3 mL) IV 15–50 mg (1
Last updated on Apr 4, 2023
For oral dosage form (tablets): Treatment of gastrointestinal motility
Some patients may require higher doses up to 20 mg three or four times daily
06 mg/kg IV or 0
Following sublingual administration of detomidine oromucosal gel, drug concentrations up to 0
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Studies from the published literature cite the most common, average dose as 2 µg pergolide/kg with a range from 0
CONTRAINDICATION Horses with hypersensitivity to domperidone should not receive EQUIDONE Gel
1 mg/kg PO every 12 hours to increase PRL blood concentration and milk production
Domperidone D2 dopaminergic antagonist Antiemetic Increases gastroesopha-geal sphincter tone 0
Indications and dose For domperidone Relief of nausea and vomiting for domperidone By mouth
Increases prolactin to supraphysiologic
Endogenous ACTH concen-trations in horses without PPID do not exhibit a similar increase
Treatment should be discontinued as soon as ovulation occurs
A limitation is that the test dose of steroid may worsen a horse or pony’s laminitis (if present)
When the calf is suckling normally and gaining weight, reduce domperidone in stepwise manner weekly to 1
Domperidone concentrations in blood plasma were measured using a validated LC-MS/MS method
Oral
Use the lowest effective dose for the shortest possible duration needed to control the symptoms
25 mg/kg/dose TID 15-30 min
Methods: In a 4-period crossover study, domperidone was administered PO at 1
It provides protection from toxins due to certain bacterial infections, and is used as an anti-inflammatory in the treatment of painful eye conditions