Trazodone is an antidepressant in the serotonin modulators class of drugs
trazodone and dextromethorphan both increase serotonin
istradefylline will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism
First, both
Trazodone is rapidly absorbed in the gastrointestinal tract after oral administration, with a bioavailability ranging from 63-91% 9 and an AUC0−t of 18193
Applies to: Cough & Cold Relief (acetaminophen / dextromethorphan / guaifenesin / phenylephrine) and trazodone
Avoid or Use Alternate Drug
Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome
trazodone + codeine avoid combo if antitussive use; otherwise use alternative or monitor resp
Dextromethorphan (Oral Route) Dextromethorphan is used to relieve coughs due to colds or influenza (flu)
Applies to: trazodone and Robitussin Allergy & Cough (brompheniramine / dextromethorphan / pseudoephedrine) Using traZODone together with brompheniramine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating
Applies to: Benadryl for the Family Dry Forte (dextromethorphan) and trazodone
dextromethorphan traZODone
Includes TraZODone indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more
This medication works by suppressing dry, hacking coughs
Using dextromethorphan together with traZODone can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or
Some people, especially the elderly, may also experience impairment in thinking
Use Caution/Monitor
There are 335 drugs known to interact with Delsym (dextromethorphan), along with 1 alcohol/food interaction
asthma/COPD