A disproportionately large change in plasma concentration may result from only a moderate dose increase
The 2010 Edition of Pharmacopoeia of the People’s Republic of China stipulates that the effective range of digoxin plasma concentration is 0
†† Notes that about 2/3 of adults considered adequately digitalized (without evidence of toxicity) have serum drug concentrations ranging from 0
0 ng/mL
Severe respiratory disease
The figure presents the cumulative survival rates for patients assigned to placebo and patients assigned to digoxin in the 3 SDC
The intestinal absorption of digoxin is essentially a passive
25 mg/day for maintenance [4,24] and plasma concentrations of 1-2ug/L are
Plasma digoxin concentrations after administration of digoxin tablets are reduced by up to one-third if metoclopramide is given at the same time [ 36–38 ]; liquid or readily
The 2010 Edition of Pharmacopoeia of the People’s Republic of China stipulates that the effective range of digoxin plasma concentration is 0
The authors conclude from these data that a change in digoxin dose should result in
The therapeutic range for serum digoxin concentration is between 0
If a loading dose is given: Digoxin serum concentration may be drawn within 12 to 24 hours after the initial loading dose administration
1970 Aug 22; 3 (5720):427–428
Background: Digoxin is one of the most widely and commonly used cardiac drug, which plays an irreplaceable role in treating heart failure and arrhythmia
Many factors affect the plasma concentration of digoxin, such as drug interactions, kidney function, and genetic polymorphisms
When switching from intravenous to oral route may need to increase dose by 20–33% to maintain the
(A) depicts digoxin concentration immediately following an IV bolus
Senlffi digoxin concentrations in the first 3-4 hours after intravenous administration are spuriously elevated
Several drugs, including sucralfate, acarbose, cytotoxic agents, and enzyme inducers, can reduce digoxin plasma concentrations
The plasma concentration alone cannot indicate toxicity reliably, but the likelihood of toxicity increases progressively through the range 1
To define the relationship between digoxin dose and plasma concentration and the changes in body growth, 1181 plasma digoxin levels were measured in 644 infants and children receiving maintenance digoxin therapy
Therefore, monitor digoxin levels when initiating, adjusting, and discontinuing telmisartan for the purpose of keeping the digoxin level within the
In 1999, Cañas and colleagues published a review titled “Evaluating the Appropriateness of Digoxin Level Monitoring”