, zonisamide, acetazolamide, or dichlorphenamide) may increase the severity of metabolic acidosis and may also increase the risk of kidney stone formation
without the use of carbonic anhydrase inhibitors, stones devel-oped
No child was treated with either acetazolamide or more than one carbonic anhydrase inhibitor simultaneously
Educate on performing a 24-hour urine study
In children and young adults, zonisamide has been shown to cause crystalluria and the withdrawal of the medication causes decrease of the crystalluria (Go 2013 )
1
Medically reviewed by Drugs
TMP inhibits carbonic anhydrase, an enzyme that is necessary for acid Topiramate inhibits renal carbonic anhydrase, which can lead to renal tubular acidosis and hypercalciuria
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Topiramate is a carbonic anhydrase inhibitor commonly used in patients with focal epilepsy
Topamax belongs to the class of medicines known as carbonic anhydrase inhibitors or carbonic anhydrase inhibitor anticonvulsants
, Despite a theoretical higher risk of kidney stones when ketogenic diets are combined with zonisamide or topiramate as both ketogenic diets and carbonic anhydrate inhibitors have been independently Kidney stones: avoid use with other carbonic anhydrase inhibitors, drugs causing metabolic acidosis, or in patients on a ketogenic diet (5
1 Is it OK to take oral acetazolamide with food? Yes—food does not delay the rate of absorption of the drug
Metabolic Acidosis: Kidney Stones: EPRONTIA can cause an increased risk of kidney stones
Risk of kidney stone formation
For those kidney stone patients who take topiramate and demonstrate hypocitraturia, potassium citrate therapy can increase urinary citrate Study with Quizlet and memorize flashcards containing terms like Topiramate MOA, Topiramate, Topiramate Dosing and more
Kidney disease or stones—Higher blood levels of carbonic anhydrase inhibitors may result, which may increase the chance of side • Kidney stones: avoid use with other carbonic anhydrase inhibitors , drugs causing metabolic acidosis, or in patients on a ketogenic diet (5
Acetazolamide is also used as an anticonvulsant to control certain seizures in the treatment of epilepsy
As a carbonic anhydrase inhibitor, topiramate can affect the pH of bodily fluids and is known to increase the risk of nephrolithiasis
The resulting alkaline urine and hypocitraturia from metabolic Kidney Stones, Carbonic Anhydrase Inhibitors, and the Ketogenic Diet According to a review of clinical trials provided by Faught et al
Calcium phosphate kidney stones have been observed with topiramate treatment, but a comprehensive elucidation of stone-risk profile was not reported previously
Topiramate, through its inhibition of CA, predisposes to the development of RTA, kidney stones and osteoporosis
HHS Vulnerability Disclosure Phentermine and extended-release (ER) topiramate have been used separately in various ways
Urinary calculi may be induced by a number of medications used to treat a variety of conditions
This new indication will likely increase the use of this agent
Methods: Since
Zonisamide is also a weak carbonic anhydrase inhibitor and seems to induce a lower incidence of kidney stones when compared to topiramate
Renal calculus: Topiramate exhibits weak carbonic anhydrase inhibitory properties and may increase the risk of kidney stones about 2 to 4 times that of the untreated population
Medically reviewed by Drugs
Talk with the doctor
An important side effect of TMP is metabolic acidosis, which is mediated by renal tubular defects
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For early detection of renal complications, regular
Renal disorders due to the removal of HCO3 or acid handling in the presence of relatively preserved GFR are collectively referred to as renal tubular
Distal renal tubular acidosis, hypo - kalemia, and the use of carbonic anhydrase in - hibitors (e
Tiredness, drowsiness, dizziness, loss of coordination, tingling of the hands/feet, loss of appetite, bad taste in your mouth, diarrhea, and weight loss may occur