Mechanism of Action Ondansetron is a selective 5-HT3 serotonin-receptor antagonist used for its antiemetic properties
Ondansetron is a first-generation serotonin (5-hydroxytryptamine or 5-HT) receptor antagonist which binds to the 5-HT 3 receptor
Mechanism of Action Ondansetron is a selective 5-HT3 serotonin-receptor antagonist used for its antiemetic properties
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The 5-HT 3 antagonists are the newest and most expensive antiemetics
Medscape - Nausea & vomiting dosing for Zofran (DSC) (ondansetron), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information
Abstract
H1 receptors in central nervous system areas include the area postrema and vomiting center in the vestibular nucleus
Ondansetron is a serotonin-3 (5-hydroxytryptamine-3, 5-HT 3) receptor antagonist, have been shown to have a good antiemetic effect in patients receiving chemotherapy and in situations with vomiting after surgery 1)
Enoxaparin is an indirect anticoagulant that binds and potentiates antithrombin III (serine protease inhibitor) through a specific
It is not certain whether ondansetron’s antiemetic action is mediated centrally, peripherally, or in both sites
Ondansetron is well absorbed orally and has an oral bioavailability of 60%
Ondansetron inhibited both emesis and all behavioural signs of nausea completely
Therapeutic Effects: Decreased incidence and severity of nausea and vomiting following chemotherapy or
Emesis itself is an adaptive mechanism that is protective, maintained through evolution to allow the body to
Besides their anti-inflammatory effects, glucocorticoids may act via the following mechanisms: (i) direct central action at the solitary tract nucleus; (ii) interaction with the neurotransmitter serotonin and receptor proteins of tachykinin NK 1 and NK 2, adrenaline, etc
It is not certain whether ondansetron’s antiemetic action is mediated centrally, peripherally, or in both sites
Promethazine is a phenothiazine derivative with antidopaminergic, antihistamine, and anticholinergic properties
(1) Mechanism of Action
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