Overall, the proportion of patients with mild (460–479 ms), intermediate (480–499 ms), and severe (≥500 ms) QTc prolongation was 9%, 4%, and 2%, respectively
The incidence of QTc interval prolongation (defined as QTc > 500 ms and/or increase of > 60 ms from baseline) was respectively 5
Drug-induced QTc prolongation is an important substrate for VA, although the incidence of potentially life-threatening polymorphic VA in daily practice seems to be low
The city is located 70 km inland from Jeddah, in a narrow valley 277 m above
Shown is the standardized protocol employed for QT interval monitoring as guided by baseline QRS duration (QRSd) and QT interval
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It is important for physicians treating COVID-19 patients to understand that there is a risk with the use of hydroxychloroquine and azithromycin, and the risk of harm should There are occasional case reports of hydroxychloroquine prolonging the QT interval and provoking torsade de pointes 1–4 when used to treat systemic lupus erythematosus
In a recent analysis from the University of Florida, >13 million reports over the last 50 years (from 1969 to 3rd Quarter of 2019) from the U
Reports from several institutions indicate that the use of hydroxychloroquine in patients with COVID-19 treated in the intensive care unit can prolong the QT interval (36% of patients)
9%), 2/9 (22%) and 24/218 (11%), respectively
Introduction: No data are provided about the effect of triple combination therapy with Lopinavir/Ritonavir (LPN/RTN), hydroxychloroquine (HQ) and azithromycin (AZT) on corrected QT (QTc) interval and arrhythmic risk, in COVID-19 patients
62%)
In early 2020, anecdotal reports and preliminary data suggested utility of chloroquine and hydroxychloroquine for attenuating viral loads and symptoms in
From a side effect profile, Agstam S, Yadav A, Kumar-M P, Gupta A
The primary outcome was the incidence of QTc prolongation ≥ 500 ms, the main secondary outcomes were the Tisdale score ability to predict QTc prolongation and the incidence of ventricular arrhythmias and sudden deaths
2-5 Thus, delineation of the determinants of significant corrected QT interval