Currently, it is believed that paracetamol is a multidirectional drug and at least several metabolic pathways are involved in its analgesic and antipyretic action
Mechanism of Action Acetaminophen is one of the most widely used over-the-counter analgesic and antipyretic medications
Synthesis of Paracetamol by Acetylation | Comprehensive Organic Chemistry Experiments for the Laboratory Classroom | Books Gateway | Royal Society of
In this context, the aforementioned
Schematic representation of the central mechanism of action of paracetamol to its antinociceptive activity
Three different experiments that allow the synthesis of the drug paracetamol are described; such experiments were designed for their implementation in undergraduate organic chemistry courses, considering the medical and economic importance of paracetamol
10 mg of paracetamol was firstly Paracetamol (N-(4-hydroxyphenyl)ethanamide), also known as acetaminophen in the USA and Japan, is a widely used over-the-counter non-salicylate and non-narcotic The mechanism for synthesizing Acetaminophen using 4-aminophenol and acetic anhydride
It was previously thought that paracetamol does not inhibit prostaglandin synthesis, despite its pharmacological and toxicological effects indicating so
Phenol (hydroxybenzene) will react with sodium nitrate (an oxidizing agent) in the presence of sulfuric acid to produce a mixture of structural isomers of nitrophenol
Paracetamol was first synthesized in 1878 by Morse, and introduced for medical usage in 1883
Mechanisms of Actions
Debate exists about its primary site of action, which may be inhibition of prostaglandin (PG) synthesis or through an active metabolite influencing cannabi-noid receptors
Paracetamol (acetaminophen) is generally considered to be a weak inhibitor of the synthesis of prostaglandins (PGs)
experience of a two-step synthesis, along with isolation and characterization of an intermediate, deacetylation of 4-aminophenol, followed by chemoselective hydrolysis of the intermediate ester (Scheme 1), was selected
Use reactions in this specification to devise a synthesis, with up to four steps, for an organic compound
NO