MMPs are present in healthy individuals, and have been shown to be involved in various physiological and Sep 15, 1999 · Tetracyclines (doxycycline and minocycline) inhibit inducible NO synthase expression and augment cyclooxygenase (COX)-2 expression and PGE 2 production
Periodontal pathogens and destructive host responses are involved in the
In view of these observations, we examined whether chemically modified tetracyclines such as CMT-3 and CMT-8, which inhibit iNOS expression and which lack
Abstract
Pharmacol Res
Chemically modified non-antibiotic tetracyclines (CMT, or COL) were tested using tumors of prostate, breast and melanomas
Chemically modified tetracyclines (CMT) have been synthesized in which the antibacterial potency has been eliminated but in which the anti-MMP efficacy is retained
The development of chemically modified tetracyclines (CMT) was the most driven by common side effects of older-generation tetracyclines, e
1996 Jul 12;52(1):105-11
The tetracyclines are organic bases with pKa values of about 8 and are, therefore, largely present as the cationic (ionized forms) in blood (Fig
Chemically modified tetracyclines (CMTs) are derivatives of tetracycline group of drugs which lack antimicrobial action but have potent host modulating affects
Due to chemical modification, CMT lacks the antimicrobial activity, due to which chances of development of antibiotic resistant microbial flora diminishes in long-term
This mechanism does not add to their antibiotic effects, but has led to extensive research on chemically modified tetracyclines or CMTs (like incyclinide) for the treatment of rosacea, acne, diabetes and various types of neoplasms
Chemically modified tetracyclines (CMTs) have shown promising activity as matrix metalloproteinase (MMP) inhibitors acting as zinc-binding groups
Tetracycline, doxycycline and minocyclineare all composed -ring core to which are attached various side groups
7548-7557
A novel approach for the treatment of periodontal disease is the use of host-modulating therapy (HMTs) along with conventional mechanical therapy
Chemically modified tetracyclines (CMTs) are one such group of drugs which have been viewed as potential host modulating agents by their anticollagenolytic property