Hence, a discussion of the mode of action of tetracyclines requires consideration of uptake and ribosomal binding mechanisms
However, the mechanism of resistance is quite different from chloramphenicol and aminoglycosides
Antibiotic Resistance Mechanisms
Changing the use of tetracyclines in human and animal health as well as in food production is needed if this class of broad-spectrum antimicrobials through the present century is to continue to be used
Chloramphenicol is a medication used in the management and treatment of superficial eye infections such as bacterial conjunctivitis, and otitis externa
1
Penicillin is a medication used to manage and treat a wide range of infections
The tetracyclines combat two key factors in acne pathogenesis with their antimicrobial effect on C
Additionally, we provide an overview of the diverse mechanisms by which bacteria obtain resistance to tetracyclines, ranging from efflux, drug modification, target mutation and the
e
It has a role as an antimicrobial agent, an antibacterial drug, an antiprotozoal drug, a protein synthesis inhibitor and
Mechanism of action
Subsequent to such binding, attachment of aminoacylt-RNA to the m-RNA-ribosome complex is interferred with (Fig
Side effects may include nausea, diarrhea, and sensitivity to light
Streptomycin, an antibiotic derived from Streptomyces griseus, was the first
The 16S rRNA binding mechanism currently held for the antibacterial action of the tetracyclines does not explain their activity against viruses, protozoa that lack mitochondria, and noninfectious conditions