Dear ILAE Task force, We congratulate for the efforts made in providing advances in neonatal seizures management; in particular, we appreciate with enthusiasm your efforts in underlining the importance of the EEG/aEEG as indispensable tools for seizure detection and believe that such inputs from the scientific community are needed to strengthen the possibility to have 24-7 Newer drugs, such as topiramate and bumetanide, are also being explored for the treatment of neonatal seizures (Glass 2011; Jensen 2009; Pressler 2015)
Topiramate for the treatment of neonatal seizures Therapeutic options for treating neonatal seizures, such as phenobarbital and phenytoin, lack efficacy and are potentially harmful to the developing brain
Therapeutic options for treating neonatal seizures, such as phenobarbital and phenytoin, lack efficacy and are potentially harmful to the developing brain
In addition, topiramate in combination with hypothermia was found to be protective in a rodent neonatal stroke model [ 71 ]
Thomas MD, MS a b Add to Mendeley Neonatal seizures have been estimated to occur in up to3-5out of every 1000 births, and preterm newborns are estimated to develop seizures more frequently than full- term newborns, with an overall incidence of1 0-15 per1,000 preterm newborns, compared with 3-5 per 1000 full-term newborns and a prevalence of 22
The Neonatal Task Force of the International League Against Epilepsy (ILAE) developed evidence-based recommendations about anti-seizure medication management in neonates in accordance with ILAE standards
Topiramate is readily used in the adult and older pediatric population for the management of migraines and partial-onset seizures
Newer drugs, such as topiramate and bumetanide, are also being explored for the treatment of neonatal seizures (Glass 2011; Jensen 2009; Pressler 2015)
In 2018, a single-institution retrospective case series described concern for an increased risk of necrotizing enterocolitis (NEC) in neonates whose refractory seizures
Topiramate for the Treatment of Neonatal Seizures Therapeutic options for treating neonatal seizures, such as phenobarbital and phenytoin, lack efficacy and are
Topiramate Is Safe for Refractory Neonatal Seizures: A Multicenter Retrospective Cohort Study of Necrotizing Enterocolitis Risk Methods
The Neonatal Task Force of the International League Against Epilepsy (ILAE) developed
The topiramate group exhibited less seizure burden in the first 24 h of hypothermia (topiramate, n = 14 [25
In a recent large multi-center review of practice variation in treatment of neonatal seizures, topiramate was used < 1% of the time; however, the paper did not specify whether topiramate was prescribed for acute symptomatic seizures or neonatal epilepsy
Neonatal seizures (NS) occur in 1
Topiramate appears effective as both an antiseizure and neuroprotective agent in animal models of newborn brain injury
We describe two siblings with neonatal hypocalcemic seizures whose mother took topiramate during both pregnancies
Topiramate has been shown to have neuroprotective Mode of action of neonatal antiepileptic drugs (AEDs)
9%) for the treatment of (symptomatic) neonatal seizures (scenario 1)
, 2013), Clonazepam (Andre 1991), Topiramate (Filippi 2010) and Oxcarbazepine
Neonatal seizures are common and frequently reflect serious underlying brain Randomised controlled trials are now underway to test the efficacy of some newer AEDs for neonatal seizures
Topiramate continues to gain favor among pediatric neurologists who often recommend this medication as a third-line treatment of neonatal seizures, and 4 preterm neonates, born between 2015 and 2017, who developed radiographic signs of necrotizing enterocolitis after receiving topiramate for seizures
This chapter summarizes the presentation, etiology, and
Topiramate appears effective as both an antiseizure and neuroprotective agent in animal models of newborn brain injury
Anti‐seizure medications act through various mechanisms, the main ones being blockage of voltage‐gated ion channels, GABA‐mediated neuronal inhibition, and blockage of
Ther Drug Monit