2013
Fluoxetine, paroxetine, sertraline, citalopram, and fluvoxamine are SSRIs mostly linked with hepatotoxicity (Table 1)
Section Editor: Peter P Roy-Byrne, MD
02% of inpatients receiving long-term therapy with fluoxetine showed elevated liver enzymes
Sertraline is a
The pharmacokinetics of other psychotropic drugs, such as diazepam and paroxetine, with less affinity for liver enzymes, are not as influenced by first-pass
2008)
Vilazodone is a selective serotonin reuptake inhibitor (SSRI) and partial serotonin receptor agonist which is used in the therapy of major depressive disorders
There are some that may carry a risk of liver damage, including green tea extract
Other common SSRIs besides Prozac include paroxetine (Paxil), sertraline (Zoloft), and escitalopram (Lexapro)
Sertraline and citalopram show linear pharmacokinetics while fluoxetine, fluvoxamine, and paroxetine show nonlinear pharmacokinetics
The major metabolic pathway of fluoxetine leading to the formation of its active metabolite, norfluoxetine, is mediated by CYP2D6
All SSRIs are thought to work in a similar way and generally can cause similar side effects, though some people may not experience any
For instance, sertraline (Zoloft) is Nortriptyline can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute and chronic cholestatic liver injury
In human liver microsomes, sertraline was N-demethylated and deaminated by cytochrome P450
Liver test abnormalities have been reported to occur in less than 1% of patients on bupropion, and elevations are usually modest and usually do not require dose modification or discontinuation
31 Several clinically Paroxetine is well absorbed from the gastrointestinal tract and undergoes first pass metabolism in the liver
Five drugs with the predominant pharmacologic effect of inhibiting the neuronal reuptake of serotonin are available worldwide for clinical use