This study presents characterization and physicochemical properties of a new cocrystal of ketoconazole (KTZ)
The in vivo study of the cocrystal indicated similar pharmacokinetic profiles and liver toxicity with increased transaminases, as reported for ketoconazole
The slow solvent evaporation method was used to
Therefore, our group has synthetized and
The PXRD diffractogram of cocrystal ketoconazole is different compared to pure component
In particular, the cocrystal form with glutaric acid showed an 1800-fold solubility increase in water concerning ketoconazole
Ketoconazole cocrystal with 4-amino benzoic acid was prepared
The cocrystal of ketoconazole‒p-aminobenzoic acid showed 10-fold higher aqueous solubility and 6
The diffraction pattern of ketoconazole cocrystal was noticeable from the individual compound
This study demonstrates in vitro and in vivo control of cocrystal dissolution with drug supersaturation/precipitation based on the solubility product of a cocrystal
Moreover, the combination of more than one virtual screening approach may significantly improve the efficiency and quality Unlike salts, the pH max of cocrystals of basic drugs and acidic coformers can occur on either side of the solubility minimum depending on pK sp and S 0,D
58O In addition, synthesized cocrystal have unique habit crystal, melting point and FTIR spectrum compared to single component
Co-crystallization is a promising technique for improving the biopharmaceutical properties of active pharmaceutical ingredients
As a class II compound in the biopharmaceutics classification system, KTZ has low aqueous solubility
) containing 20 mL of either FeSSIF media or corresponding aqueous buffer Cocrystals and salts are long-known multi-component crystalline assemblies and have been attracting expanding interest among pharmaceutical scientists [17,18,19,20]
The 1:1 cocrystal of the antifungal agent Ketoconazole with p-aminobenzoic acid was successfully crystallized and systematically characterized from a physical and pharmacological point of view
original article
These CIF files were used to compare the crystal structure of our made cocrystals and salts to that of the published standard to identify closeness and determine purity using TOPAS software in