Inhibits Na+ reabsorption that occurs more distally in the nephron For decades, spironolactone was favored over loop diuretics
This is particularly true for ascites due to peritoneal carcinomatosis, in which sodium restriction and diuretics cause intravascular volume depletion without
The estimated probabilities of survival at
Forty nonazotemic cirrhotic used in the study, spironolactone is more effective patients with ascites and avid sodium retention than furosemide in nonazotemic cirrhosis with asci-
Decrease in BP
Treatment of ascites in liver cirrhosis with spironolactone as the primary agent is highlighted with further therapeutic options
The
Background/Aims: The most rational treatment of moderate ascites is spironolactone alone or in combination with furosemide
This study was an analytical observational study with retrospective cohort design
A combination treatment with furosemide might be necessary in patients who do not respond to spironolactone alone
Thus, uncontrolled ascites is often the reason for hospital admission in patients with decompensated cirrhosis ,
The newer loop diuretic torsemide is more potent than furosemide and has been shown to be as effective and safe as furosemide in a small study of 46 cirrhotics with ascites
Spironolactone (Aldactone) is a type of potassium-sparing diuretic (water Introduction: The present study was conducted to compare the efficacy and side effects of Spironolactone and Eplerenone in management of ascites due to liver cirrhosis
Furosemide is a loop diuretic and the most commonly administered diuretic to treat CHF in dogs, cats, cattle, and horses
Patients with cirrhosis and ascites must limit sodium intake to 2 gram per day
1016/0016-5085(83)90198-1 Corpus ID: 77828304; Randomized comparative study of efficacy of furosemide versus spironolactone in nonazotemic cirrhosis with ascites: Relationship between the diuretic response and the activity of the renin-aldosterone system Ascites is the most common complication related to cirrhosis and is associated with increased morbidity and mortality
The development of ascites is the most frequent decompensation event in patients with liver cirrhosis
Spironolactone potentiates thiazide or loop diuretics by antagonising aldosterone; it is a potassium-sparing diuretic
(2000 mg) per day, and treating with diuretics (spironolactone and furosemide in a ratio of 100:40 mg/day) Patient with a treatable
Methods: Forty-six patients were randomized in two groups to receive torsemide 20 mg/day (n = 22) or frusemide 40 mg/day (n = 24)