Go to: In influenza A, the mechanisms of action of amantadine are thought to be related to the interference with the endosome by causing its alkalinization and disrupting the proton channels, thus interrupting the release of virions into the cell [ 1 ]
Amantadine for COVID-19
"In fact, there are many classic drugs that might be useful for management of COVID-19
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Moreover, Amantadine by improving cognitive impairment, which is common in post-COVID-19 patients, with the effect of mental arousal can enhance the suppressed respiratory response to hypoxia and hypercapnia 39, 40
Wiwanitkit 7 afirma que hay muchos fármacos clásicos que podrían ser útiles para el tratamiento de la COVID-19, entre ellos la amantadina
Despite its prevalence, limited research has explored effective treatments for post-COVID-19 fatigue
Coronavirus; Health Paxlovid is another drug approved to treat COVID-19 in adults
It is well known that PD symptoms may deteriorate during systemic infections leading to symptoms ranging from mild worsening to frank akinetic crisis [12]
Extended-release capsules: Initial dose: 137 mg orally once a day at bedtime
Amantadine was used in the early 2000s for Influenza A treatment
Side effects reported in other studies include suicidal ideation and attempts (some fatal) with and without a history of psychiatric disorders
Amantadine-Induced Cardiac Arrest in a Patient With COVID-19 Cureus
While these findings may favor amantadine as a treatment for COVID-19, further studies are necessary to determine its safety and effectiveness
During the Corona pandemic, its effect to inhibit SARS-CoV-2 in vitro has been investigated
COVID-19-Associated Benzodiazepine-Resistant Catatonia Responds to Amantadine
sore throat
Human coronaviruses can sometimes cause lower-respiratory tract illnesses, such as pneumonia or bronchitis
They mainly act as N-methyl-D-aspartate antagonists
It may cause greater amounts of dopamine to be released in the brain
SARSCov- 2 entry into a cell is dependent upon binding of the viral Spike (S) protein to cellular receptor and on cleavage of the spike protein by the host cell proteases such as Cathepsin L and Cathepsin B (CTSL/B)
2020;54(3):284-285
Less common side effects Background: Amantadine has been proposed as a treatment for COVID-19 because it shows anti-SARS-CoV-2 activity in vitro
Several studies are currently being conducted worldwide to assess the potential effect of amantadine on COVID-19 infection [, , ]
Low-potency neuroleptics and alpha-2 adrenergic agents may be especially useful in this setting
arcmed
PMCID: PMC8636635 DOI: 10
of COVID-19 patients with amantadine5 suggested a positive impact
Although there is no sequence homology of the influenza A and SARS-CoV-2, amantadine inhibits two of the four known (protein 3a and E) or putative (Orf7b and
Araújo et al
Interpretation: Amantadine is associated with a reduced risk of COVID-19 infection after adjusting for a broad range of variables
The intervention group received Amantadine for two weeks, while the control group received no treatment
Amantadine hydrochloride is one of the most commonly prescribed medications for patients with disorders of consciousness who are undergoing inpatient neurorehabilitation
[7] [8] It acts as a nicotinic antagonist, dopamine agonist Amantadine is an NMDA antagonist
It was approved by the US Food and Drug Administration (FDA) for the treatment of influenza A in 1976 and was used as such until point mutations in the influenza A genome resulted in increasing resistance; CDC
This may be from migration of severe acute respiratory syndrome coronavirus 2
Comments: This clinical trial will assess the efficacy and safety of amantadine in the prevention of COVID-19 progression toward acute respiratory failure and neurological complications
, 2001)
Amantadine, which is known for its antiviral activity, is presently used as therapy for Parkinson's disease
7759/cureus
" Subjects will be assigned randomly to two groups
We aimed to evaluate the effectiveness of amantadine in preventing the progression of COVID-19 and its neurological sequelae
2022 Nov 17;24(6):22cr03394
It’s also used to treat drug-induced movement problems, and to prevent and treat infection with influenza (flu) A virus