Though the exact mechanism of action remains unknown, research suggests that DNA synthesis is blocked by interfering with the activity of an enzyme that is important for the process
Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase
[1] hydroxyurea [2] fludarabine, cladribine, gemcitabine, tezacitabine, and triapine [3] gallium maltolate Hydroxyurea (HU) is a widely used cytotoxic agent that is known to induce fetal hemoglobin (HbF) production and is presently used to ameliorate the severity of pain episodes in patients with sickle cell anemia (HbSS)
Hydroxyurea is a well-established inhibitor of ribonucleotide reductase that has a long history of scientific interest and clinical use for the treatment of neoplastic
DNA replication inhibitor hydroxyurea alters Fe-S centers by producing reactive oxygen species Meng-Er Huang Céline Facca Zakaria Fatmi Dorothée Baïlle
Hydroxyurea (HU), an FDA-approved drug for treating sickle cell disease, is used as an antitumor drug alone and together with conventional chemotherapeutics or
Hydroxyurea (HU), an antineoplastic drug used for treatment of HIV, cancer, and myeloproliferative diseases (Kovacic, 2011) slows the progression of DNA replication
Although hydroxyurea is a weak inhibitor, in comparison with the 3 other RNR inhibitors tested, the authors further explain that this level of inhibition may be of
This is not a complete list of side effects and others may occur
Hydroxyurea is used in a number of myeloproliferative, neoplastic, HIV, and non-hematological diseases [1]
, Mehta, R
Hydroxyurea (HU) is a widely used cytotoxic agent that is known to induce fetal hemoglobin (HbF) production and is presently used to ameliorate the severity of pain episodes in patients with sickle cell anemia (HbSS)
The inhibit
8 – 11 Globally, it has emerged as a major advancement in the treatment of SCD as it is one of the Hydroxyurea (HU) is an anti-leukaemia and anti-tumour drug which has also found limited application in the treatment of dermatological disorders
Namely, HU provokes a deoxyribonucleotides, double-strand DNA breaks near to replication forks, and inhibits both nuclear and
These medications inhibit the activity Ribonucleotide reductase inhibitors hydroxyurea, didox, and trimidox inhibit human cytomegalovirus replication in vitro and synergize with ganciclovir
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HU is an antimetabolite that inhibits ribonucleotide reductase, which causes a depletion of the deoxyribonucleotide pool and dramatically reduces cell
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The 'old favourites' used for treatment of inflammatory diseases, and hence, the original immunomodulators, include the glucocorticoids, azathioprine, methotrexate and hydroxyurea
5 hrs in sporulation medium) allow the
It is a potent inhibitor of DNA synthesis in many organisms from viruses to man and in cell culture systems