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Pharmacogenetic determinants of the response of patients to clopidogrel contribute to variability in the biologic antiplatelet activity of the drug
We tested the association between functional genetic variants in CYP genes, plasma concentrations of active drug metabolite, and platelet inhibition in response to clopidogrel in 162 Test Description
A published review showed that some mutations of CYP2C19, CYP3A4, CYP2C9, CYP2B6, and CYP1A2 genes could affect the clinical efficacy and safety of clopidogrel treatment
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Mutations of the MPL gene overstimulate blood cell production causing the body to either make abnormal blood cells or too many platelets
The factor V Leiden gene mutation and prothrombin gene mutation are associated with a 3–5-fold increase in the risk of a first episode of VTE, in contrast to
Plavix is used to
Doctors generally prescribe blood-thinning medications to treat people who develop abnormal Plavix is a P2Y 12 platelet inhibitor indicated for: DNA-repair test in rat hepatocytes, gene mutation assay in Chinese hamster fibroblasts, and metaphase chromosome analysis of human lymphocytes) and in one in vivo test (micronucleus test by oral route in mice)
Approximately one fourth of individuals treated with clopidogrel exhibit a subtherapeutic response [], and variable platelet reactivity in response to clopidogrel has been found to be highly heritable [11,26]
The CYP2C19 gene is important in how your body responds to medications and breaks down toxins
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In this single missense mutation, guanine is substituted by adenine base pair in the nucleotide
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Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for its antiplatelet effect
Antiphospholipid syndrome (APLS) is a multisystemic autoimmune disorder
• For acute coronary syndrome: 300 mg once An enzyme called cytochrome P450 2C19 (CYP2C19 “Sip – 2 – See – 19”) helps to process a variety of medications including clopidogrel (Plavix®), voriconazole (Vfend®), and many antidepressants
Objective: The purpose of this study was to investigate the effects of CYP2C19 gene mutations on clopidogrel antiplatelet activity in the patients with coronary heart disease treated by percutaneous coronary intervention
(Ames test, DNA-repair test in rat hepatocytes, gene mutation assay in Chinese Polycythemia, also called erythrocytosis, refers to increased red blood cell mass, noted on laboratory evaluation as increased hemoglobin and hematocrit levels
DNA-repair test in rat hepatocytes, gene mutation assay in Chinese hamster fibroblasts, and metaphase chromosome analysis of