Clopidogrel is an inactive prodrug that requires enzymatic activation via a variety of CYP enzymes, including the CYP2C19 and CYP3A4 enzymes, through a two-step process of bioactivation
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What Is Plavix? Plavix (clopidogrel bisulfate) is a thienopyridine class of drug that inhibits platelet aggregation and thus inhibits aspects of blood clotting used to
It keeps platelets in your blood from coming together and making clots
Diarrhoea 2
Thrombocytopenia (are) Contra-indications of Clopidogrel 1
Instruct the patient to continue taking clopidogrel as recommended and not to stop abruptly without consulting a doctor
3 Pharmacokinetics 12
List the adult dosage for clopidogrel/plavix
Pharmacology Mechanism of action
It belongs to a class of drugs called platelet inhibitors
Time OD
Common carvedilol side effects may include: weakness, dizziness; Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease)
Over time, numerous antiplatelet agents have been developed with a multitude of indications
1), Clinical Pharmacology (12
6 It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots
Paul, M
dual anti-platelet therapy with clopidogrel vs clopidogrel + omeprazole
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Remember that Clopidogrel oral tablet is a prescription drug that’s available as the brand-name drug Plavix
Studies often look at PPIs as a class, with some showing PPIs are associated with poorer cardiovascular outcomes when taken with clopidogrel
Clopidogrel targets, irreversibly binds to and alters the platelet receptor for adenosine diphosphate ( ADP ), thereby blocking the binding of ADP to its receptor, inhibiting ADP -mediated activation of the glycoprotein complex The effectiveness of clopidogrel results from its antiplatelet activity, which is dependent on its conversion to an active metabolite by the cytochrome P450 (CYP) system, principally CYP2C19 [see Warnings and Precautions , Clinical Pharmacology ]