Sep 1, 2022 · Loperamide is a widely available nonprescription drug used primarily for the treatment of diarrhea
Loperamide-induced cardiogenic syncope: a case report of a life-threatening presentation of an over-the-counter drug Vishwajit Hegde, Tarun Dalia, Taher Tayeb, Elizabeth Cotter, and Andrija Vidic Mark Abela, Handling Editor, Patrick Badertscher
Loperamide is a nonprescription opioid widely used for the treatment of diarrhea
Loperamide is a widely available, over-the-counter medication
Patients will often present with recurrent, unexplained syncope accompanied with marked electrocardiographic abnormalities including QT-interval prolongation
Conclusion: Loperamide overdose is a toxidrome that remains underrecognized, and in patients with unexplained cardiac arrhythmias, loperamide
In cases of abuse, individuals often use other drugs together with loperamide in attempts to , 6 Although loperamide is relatively safe at therapeutic doses, there have been recent and increasing reports of toxicity, many of them fatal, resulting from high
Analysis of loperamide-related European Medicines Agency (EMA) pharmacovigilance database reports Misuse-; abuse; and overdose-related ADRs (n
The use of loperamide in high doses has been associated with a significant increase in morbidity
Loperamide is a nonprescription opioid widely used for the treatment of diarrhea
30,33 However, it is important to note that naloxone administration will not affect the Loperamide non-cardiac arrhythmia overdosages should be treated as opioid overdosages
In adults and pediatric patients, naloxone may be administered intravenously
Cases of syncope and ventricular tachycardia have been reported in adult patients receiving the recommended dosage of Loperamide Hydrochloride Capsules
Torsades de Pointes or other ventricular arrhythmias, syncope, and cardiac arrest
1 Loperamide-induced cardiotoxicity has been related to inhibition of the delayed rectifier current (IKr) channels, and NaV1
INTRODUCTION Syncope is a clinical syndrome in which transient loss of consciousness (TLOC) is caused by a period of inadequate cerebral blood flow and oxygenation, most often the result of an abrupt drop of systemic blood pressure
A 32-year-old male developed recurrent ventricular tachycardia after taking mega doses of loperamide and famotidine in order to experience an opiate-like euphoric effect
(male sex, 481/792 [61%]; age 18 to 44 years, 443/792 [56%])
The exact mechanism of loperamide-in-duced cardiotoxicity is unknown, but it is likely related to alterations in cardiac ion currents and action potential Hence, we aimed here at assessing the loperamide-related cases being reported to the EMA's EudraVigilance (EV) database
9% of cases; remaining, polydrug, cases included antidepressants; benzodiazepines; and other OTCs
loperamide as an opioid alternative to relieve symp-toms of narcotic withdrawal [4]
CPR and ACLS should be considered first-line treatment for cardiopulmonary arrest caused by loperamide overdose
Loperamide is opioid-related and like meperidine (pethidine) is a piperidine derivative
, a professor of pharmacology and toxicology, and director of the neuroscience program at Michigan State University, says no