Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor widely used as an antidepressant and for neuropathic pain
Type Small Molecule Like all medicines, duloxetine can cause side effects in some people
Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight
Capsules
It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686
Major depressive disorder (MDD) is the most prevalent psychiatric disease and has been recognized as a critical target of intervention in the psychiatric field (3, 4)
Duloxetine is an SNRI antidepressant
Azstarys
The Cancer and Leukemia Group B (CALGB/Alliance) conducted 170601 (NCT00489411), a randomized Phase III double-blind placebo-controlled crossover trial to assess whether duloxetine 60 mg taken orally once daily decreases CIPN pain severity
The bottom line
Cymbalta’s more common side effects include: fatigue (lack of energy) nausea
* To learn more about this side effect, see Dosage of Cymbalta
At this dose, there was moderate quality evidence that duloxetine reduced pain in both painful diabetic peripheral neuropathy and fibromyalgia
The manufacturer recommends “gradual reduction in the dose,” but does not Abstract
Nausea, dry mouth, constipation, loss of appetite, tiredness, drowsiness, or increased sweating may occur
Approximately 7% of patients on the drug report decreased appetite
Pro: Significant reduction of neuropathic pain, stabilized physiological functioning, reduced compulsatory thoughts and behaviors, improved sense of well-being, and suppressed appetite
The general approach to management of chronic non-cancer pain and nonpharmacologic therapies are discussed separately
Venlafaxine and duloxetine offer the advantage of being effective for depression and anxiety Neuropathic Pain
Has been used for the management of moderate to severe stress urinary incontinence (SUI) † [off-label] in women