The nonstructural protein 2C is a AAA+ helicase and plays a key role in
This is the first report to describe the use of fluoxetine as a potential therapy for chronic enterovirus infection
Enteroviruses (EV) are a group of positive-strand RNA (+RNA) viruses that include many important human pathogens (e
1001/jamaneurol
Enterovirus infections pose a serious threat for patients with humoral deficiencies and may be lethal, whilst the efficacy of proposed treatment options such as corticosteroids, intravenous immunoglobulins and fluoxetine remains debated
[ 44 – 46 ] Unfortunately, achievable serum concentrations of fluoxetine and its active metabolite norfluoxetine are lower than inhibitory thresholds likely to be required to treat systemic disease [ 45 ]; CSF The human neonate is uniquely susceptible to serious, often fatal enterovirus infections in the first 2 weeks of life that are associated with acute maternal illness, premature delivery, male gender, and absence of maternal antibody against the infecting enterovirus serotype
Fluoxetine (Prozac®) is a selective serotonin-reuptake inhibitor that is used93 clinically for the treatment of major depression and anxiety disorders25
Neurology
Objective: To determine the safety, tolerability, and efficacy of fluoxetine for proven or presumptive enterovirus (EV) D68-associated acute flaccid myelitis (AFM)
The Enterovirus (EV) genus consists of a large number of RNA viruses belonging to the family Picornaviridae, including human enterovirus groups A, B, C, and D as well as non-human enteroviruses (Zoll et al
Fluoxetine is well tolerated but is not effective for patients with proven or presumptive enterovirus D68-associated acute flaccid myelitis (AFM), according to a study published online November 9 This is the first case report of combined therapy with favipiravir, fluoxetine, and high-dose IVIg in the context of severe enterovirus encephalitis in an immunocompromised host
We report that fluoxetine (Prozac)—a selective serotonin reuptake inhibitor—inhibits the replication of human enterovirus B (HEV-B) and HEV-D but does not affect the replication of HEV-A
JAMA Neurol 2015;72:493–494
Human enteroviruses are members of a genus containing more than 100 distinct RNA viruses responsible for various life threatening infections, such as poliomyelitis and encephalitis