Disulfiram
It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol
Nausea and vomiting
For more ideas about how to limit Herxheimer reactions, see Herxheimer Reactions:
Recently, disulfiram has been proposed as a promising treatment for people suffering from persistent symptoms of Lyme Disease
Kenneth Liegner described the use of disulfiram (DSF) in three patients with chronic relapsing borreliosis
To help overcome drinking problems: Adults and teenagers—At first, the dose is 500 milligrams (mg) or less, once a day for one or two weeks
Most recently, disulfiram has received attention as a potential treatment for Lyme disease [10,85]
The full dose for an average adult is 500 mg daily
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Disulfiram is one of three drugs approved by the Federal Drug Administration (FDA) to treat alcohol dependence
Disulfiram works by blocking the breakdown of alcohol in the body
High acetaldehyde causes uncomfortable symptoms including flushing, throbbing in head and neck, nausea, vomiting, diaphoresis
Flushing or redness of face
Disulfiram side effects
Disulfiram works by interfering with the way your body breaks down
Disulfiram has been associated with a low rate of with serum aminotransferase elevations during chronic therapy and has been linked to clinically apparent acute liver injury which
High levels of acetaldehyde produce feelings similar to a hangover, which are intended to help people stop drinking
Approximately 5-20% is not metabolized and is excreted unchanged in the feces; the remainder is metabolized to both toxic and nontoxic metabolites
Disulfiram-induced psychosis may be more common at doses of 500 mg/day
Disulfiram is absorbed slowly from the gastrointestinal tract and is eliminated slowly from the body
Side Effects Of Disulfiram
alcohol dependence [125-500 mg PO qam] Start: 500 mg PO qam x1-2wk; Max: 500 mg/day; Info: pts must be abstinent from alcohol for >12h 2
Oral