Ashwagandha may be safe when taken in the short term (up to 3 months)
Chemical and Drug Induced Liver Injury* / etiology
Discussion: Withanolides are the active components of Ashwagandha
Ashwagandha’s side effects are rare, according to “Natural Physician’s Healing Therapies,” by Mark S2939 Ashwagandha Toxicity: A Rare Case of Drug Induced Live : Official journal of the American College of Gastroenterology | ACG S2939 Ashwagandha Toxicity: A Rare
Methods
Abstract Herb-induced liver injury (HILI) caused by herbal supplements, natural products, and products used in traditional medicine are important for differential
A popular Ayurvedic herb, ashwagandha is often used in formulations prescribed for stress, strain, fatigue, pain, skin diseases, diabetes, gastrointestinal disease, rheumatoid arthritis, and epilepsy
easing chest pain
(2020) Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network
Ashwagandha is an Indian herbal supplement that is widely available over the counter and online, with immunostimulatory effects and may lead to kidney allograft rejection
Patient's liver enzymes continued to downtrend (AST=929, ALT=765, Tbili=22
The medicinal herb appears to help lower levels of cortisol, a hormone produced by your adrenal glands in response to stress
Preliminary research shows that it may improve thyroid levels in those with hypothyroidism
This therapeutic effect of ashwagandha was mediated by the liver low-density lipoprotein receptor-related protein
Withania somnifera (Ashwagandha) Ashwagandha is a herbal extract derived from the roots of Withania somnifera, an evergreen shrub endemic to India and Southeast Asia, commonly known as the Indian ginseng or winter cherry
The first case report of ashwagandha-induced liver injury was reported in Japan in a 20-year-old man who had taken it combined with anti-anxiety drugs in doses more than twice the Huntington’s disease is a genetic disorder that causes oxidative damage and a progressive breakdown of brain cells
Later, similar cases of liver toxicity due to Ashwagandha consumption were reported from the USA and Iceland
Swelling in the legs and ankles
Drug-induced liver injury became one of the most important liver disorders and diagnostic challenge for clinicians and pathologists
It has been shown to possess anti-inflammatory, antioxidant and hepatoprotective effects which can help protect the liver from damage caused by various diseases
Therefore Ashwagandha can be used to treat Alzheimer's, Parkinson's, Huntington's and other neurodegenerative diseases at any stage of the disease, even before a person has been diagnosed and is still in the state of mild forgetfulness, etc
Ashwagandha dosage for cognitive health and memory: about