Depakote and valproic acid conversion

The therapeutic uses of VPA include epilepsy treatment across different seizure types, bipolar disorder management, and migraine prophylaxis. The mechanism of action for VPA involves the enhancement of inhibitory neurotransmission and the If valproate is to be used during pregnancy, the lowest effective dose should be prescribed in divided doses to avoid peaks in plasma-valproate concentrations; doses greater than 1 g daily are associated with an increased risk of teratogenicity

2024-03-28
    Is topiramate a blood thinner
  1. Maximum dose: 60 mg/kg/day
  2. Bipolar 1 depression: as Second line