The purpose of this study was to identify the critical variables that influence the oral absorption of azithromycin in adults and pediatrics
The number of drug candidates that are poorly water soluble has lately surged in drug development
Originally, BCS was developed to classify APIs into four classes based on their intestinal permeability and aqueous solubility (Class I: high solubility, high permeability; Class II: low solubility, high permeability; Class III: high solubility, low permeability; and Class IV: low solubility, low permeability); later, several researchers propose The FDA's Biopharmaceutics Classification System (BCS) 1 is based on the work of Amidon and coworkers 2 with the core idea being that in vitro methodology, centrally embracing permeability and solubility, with qualifications related to pH and dissolution, may qualify drug products for a waiver of in vivo bioequivalence studies
Azithromycin (AZI) belongs to the class of macrolide antibiotics that has limited water solubility and belongs to Biopharmaceutical Classification System Class II
The "high solubility" definition of the current FDA guidance on biopharmaceutical classification system may be too strict for acidic drugs
Azithromycin (AZ) is known as a macrolide antibiotic that is commonly consumed by the pediatric population for diseases such as otitis media, acute bacterial sinus, tonsillitis, pharyngitis, pneumonia, skin infections, and bronchitis ( 1 )
[1] This system restricts the prediction using the parameters solubility and intestinal permeability
It has many benefits due to its immunomodulatory, anti‐inflammatory, and
Azithromycin (AZI) belongs to the class of macrolide antibiotics that has limited water solubility and belongs to Biopharmaceutical Classification System Class
Conflicting evidence has been found regarding the BCS classification of azithromycin
Using a devised pediatric BCS framework, there was agreement in adult and pediatric BCS class for two drugs, azithromycin (class 3) and ciprofloxacin (class 4)
In this study, two nonionic polymeric surfactants, namely Pluronic L-35
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Older adults may be more likely to have side effects on heart rhythm, including a life-threatening fast heart rate
Class IV drugs exhibit a lot of problems for effective oral administration
Common azithromycin side effects may include: diarrhea; nausea, vomiting, stomach pain; or
Azithromycin side effects (more detail) Azithromycin is an antibiotic drug
BCS-based biowaivers are applicable to drug products where the drug substance(s) exhibit high solubility and, either high permeability (BCS Class I) or low permeability (BCS Class III)
Azithromycin is an antibiotic listed in the essential list of medicines for adults and pediatrics
Azithromycin is used to treat certain bacterial infections in many different parts of the body
Azithromycin is a widely used antibiotic medication that belongs to the macrolide class of drugs
Biopharmaceutical Classification System :An Account
The BCS classification system is used to categorize drugs and serves to help anticipate whether drugs will have bioavailability/ bioequivalence problems
Based on the biopharmaceutical classification system, AZI has been classified as a class II drug, where, the rate-limiting step of the drug absorption is the dissolution of the drug which indicates low bioavailability [4, 5]