Disulfiram and bipolar affective disorder
Bipolar Disorders publishes research of relevance to the basic mechanisms, clinical aspects, or treatment of bipolar disorders and related illnesses
Food and Drug Administration (FDA) to treat chronic alcohol dependence
eye pain or sudden vision loss; numbness or tingling; confusion, unusual thoughts or behavior; or
Disulfiram "significantly and dose-dependently" increased the time spent in the open arms of the EPM, compared with the vehicle-treated group, at 30 minutes after
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It works best for patients who can achieve initial abstinence of at least 12 hours, are committed to maintaining abstinence, and agree to take the medication
However, disulfiram increase the nickel retained in brain tissue, possibly accounting for its limited efficacy
Disulfiram is used alongside other treatments and counselling for alcohol dependency
1 DSF has since been used clinically, and numerous studies and clinical trials have shown that it is a safe drug without significant side effects at the US FDA
Initial dose: 500 mg orally once a day (this dose is generally continued for the first 1 to 2 weeks) Maintenance dose: 250 mg orally once a day (range: 125 mg to 500 mg once a day) Maximum dose: 500 mg once a day
Today, Antabuse is typically replaced or used with newer drugs like Revia, Vivitrol (naltrexone), and Campral (acamprosate)
Average maintenance dosage: 250 mg daily (range: 125–500 mg daily) until patient is fully recovered socially and a basis for permanent self-control is established
Approximately 200,000 alcoholics take disulfiram, or Antabuse, regularly in the United States
Introduction
Antabuse side effects vary from person to person, but some of the most commonly noted minor side effects include: Drowsiness
However, many people have no side effects or only have minor side effects
In the first phase of treatment, a maximum of 500 mg daily is given in a single dose for one to two weeks
Of the total drug interactions, 16 are major, 162 are moderate, and 15 are minor
liver problems --nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin