May 5, 2005 · Mode of action Clomiphene contains an unequal mixture of two isomers as their citrate salts, enclomiphene and zuclomiphene
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Progestin-Primed Ovarian Stimulation with Clomiphene Citrate Supplementation May Be
The Sprague Dawley rats were randomly divided into control, model, and CC groups
Clomiphene citrate is considered as the drug of choice for first line treatment of anovulatory dysfunction for a variety of reasons
It is usually taken once a day for 5 days, beginning on or about day 5 of the cycle
Clomiphene binds to this receptor and blocks the effects of estrogen on the pituitary gland
MeSH terms Clomiphene citrate (CC) is the best initial treatment for the large majority of anovulatory infertile women
cannot be determined
Anti-oestrogen which induces gonadotrophin release by occupying oestrogen receptors in the hypothalamus, thereby interfering with feedback mechanisms; chorionic gonadotrophin is sometimes The patients likely to benefit from clomiphene citrate are patients diagnosed with polycystic ovarian syndrome (PCOS) and other causes of infertility such as post-oral-contraceptive amenorrhea, amenorrhea-galactorrhea syndrome, psychogenic amenorrhea as well as some cases of secondary amenorrhea
Increased FSH and LH stimulates ovarian follicle maturation, ovulation and development of the corpus luteum
Clomiphene citrate is the initial treatment of choice for most anovulatory or oligo-ovulatory infertile women
On day 11 or 12 of the menstrual cycle, ultrasound monitoring is conducted to determine if an ovarian follicle or follicles have developed
Mechanism of action of clomiphene citrate: a paradigm for anti-oestrogen E
Mechanism of Action
The results of individual randomized controlled trials (RCTs) comparing letrozole with CC have been presented in Table 1
She is also prescribed clomiphene citrate to treat her infertility