These procedures started with adamantane 2 using as many as four reaction steps to produce amantadine hydrochloride with overall yields ranging from 45% to
It is also used as an anti-dyskinetic agent to treat Parkinson’s
Amantadine is a member of the class of adamantanes that is used as an antiviral and antiparkinson drug
GI Effects
The synthesized compounds were successfully
Increasing resistance has limited the use of amantadine and rimantadine in the treatment of influenza A
Excess methyllithium is then added to create methyl ketones which when reduced with lithium aluminum hydride gives the amine group
INTRODUCTION: Amantadine hydrochloride (1-amino-adamantane hydrochloride) (1) is an antiviral drug, which was used to treat certain influenza infections type A
However, high levels of resistance have emerged recently, initially from Asia and now in North America
It has also been used for alleviating early symptoms of Parkinson’s disease
To determine whether SARS-CoV-2 Protein E ion channel activity could be blocked oral: The drug is used for headache, nausea, malaise and some CNS effects
is the most important toxicity; occurs especially in those with kidney disease; normalises on discontinuation of the drug; Amantadine An analysis of the action mechanism of known antiviral drugs concluded that they can increase the cell’s resistance to a virus (interferons), suppress the virus adsorption in the cell or its diffusion into the cell and its deproteinisation process in the cell (amantadine) along with antimetabolites that causes the inhibition of nucleic acids This drug may be added to levodopa based therapy, with or without concomitant dopaminergic medications; adding this drug to optimal well-tolerated doses of levodopa may smooth out fluctuations that can occur with levodopa alone; patients reducing levodopa dose due to side effects may regain lost benefit with the addition of amantadine
This channel is the target for the adamantane family of antiviral drugs and has recently become a popular topic for research in this area [6-8]
Once phosphate groups are added by either viral or host cell enzymes, the drugs now chemically resemble normal DNA nucleotides, the building block molecules for DNA synthesis
The first step involves the synthesis of adamantyl oxobutanamide by nucleophilic substitution reaction
The parent drug “adamantane” was found to be inactive, but when the “R” is substituted with a phenyl ring, compound 26 (IC 50 = 464
Amantadine is an FDA approved drug that has been widely used in antiviral and antiparkinsonian therapeutic areas
These procedures started with adamantane 2 using as many as four reaction steps to produce